Product Code

:  SSPC-A00393

CAS No.

:  171887-03-9

Chemical Name

:  N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

Synonyms

:   NA

Molecular Formula

:   C₅H₄Cl₂N₄O

Molecular Weight

:  207.02

Appearance

:  Off-White to Pale Beige Solid

Storage

:  2-8°C Refrigerator

Application

:  N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide (Abacavir - In House Impurity) is an intermediate of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate, which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.