Product Code

:  SSPC-A01059

CAS No.

:  945553-91-3

Chemical Name

:  (R)-Afatinib

Synonyms

:   (R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; ent-Afatinib;

Molecular Formula

:   C₂₄H₂₅ClFN₅O₃

Molecular Weight

:  485.94

Appearance

:  Pale Beige to Pale Brown Solid

Storage

:  2-8°C Refrigerator

Application

:  (S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.