Abacavir sulfate :- Impurity D — Impurity Reference Standard

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Product Code: SSPC-A00382
CAS No.: 783292-37-5
Chemical Name: Trans-Abacavir
Synonyms: [(1R,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl]methanol (as per EP); 9-[(1R ,4S )-4-(tert-Butoxymethyl)cyclopent-2-enyl]- N 6 -cyclopropyl-9H -purine-2,6-diamine (as per USP);
Molecular Formula: C14H18N6O
Molecular Weight: 286.34
Appearance: NA
Storage: 2-8°C Refrigerator
Application: Trans-Abacavir (Abacavir EP Impurity D) is an impurity of Abacavir). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.