Abacavir sulfate :- Impurity D — Impurity Reference Standard

Buy Abacavir sulfate :- Impurity D (CAS 783292-37-5) impurity reference standard from Spectrasynth Pharmachem. Custom synthesis available — enquire for pricing, COA and availability.

• Product Code: SSPC-A00382
• CAS No.: 783292-37-5
• Chemical Name: Trans-Abacavir
• Synonyms: [(1R,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl]methanol (as per EP); 9-[(1R ,4S )-4-(tert-Butoxymethyl)cyclopent-2-enyl]- N 6 -cyclopropyl-9H -purine-2,6-diamine (as per USP);
• Molecular Formula: C14H18N6O
• Molecular Weight: 286.34
• Appearance: NA
• Storage: 2-8°C Refrigerator
• Application: Trans-Abacavir (Abacavir EP Impurity D) is an impurity of Abacavir). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.